Adenoid cystic carcinoma or AdCC is an atypical type of adenocarcinoma illustrating the cancer that develops in the glandular tissues. AdCC is present chiefly in the regions of the head and neck, however could at times develop in the uterus among females or in other areas of the body.
AdCC prevalently is found in the salivary glands that comprise of a collection of secretory cells dispersed all through the inner areas of the URT or upper respiratory tract hence could be found in the regions of the oral palate, nasopharyngeal area, the base of the tongue, the internal mucosa lining of the oral cavity, laryngeal and tracheal area and main salivary glands located on the face.
Irrespective of where it originates, it has a tendency of spreading all along the nerves or via the blood. Only in five to ten percent of the cases it is observed to metastasize to the lymph nodes, the prevalent region of spreading being the lungs.
AdCC has been observed to stay dormant for protracted spans of time following which display proliferation surges. Nonetheless, AdCC could turn belligerent in few individuals which make the path of AdCC capricious.
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AdCC is mostly detected among individuals aged forty to sixty years of age, though even childhood AdCC has been found. Female gender is more prone to be detected with AdCC as compared to males.
The rate of progression of the AdCC tumor is mostly gradual and individuals could have lengthy existence with metastatic ailment, but a belated relapse is prevalent and could arise several years subsequent to the foremost treatment.
Risk Factors
Though the reason for AdCC arising is unclear, however there has been some proof which indicates that the p53 tumor suppressor gene – a gene which curbs cell development by supervising the rate of cell division, that is in some way in an inactive state during the advanced and belligerent AdCC types.
Adenoid Cystic Carcinoma Symptoms
Several individuals could feel some symptoms whereas others could be totally asymptomatic. The foremost signs arise depending on the site of the tumor.
Foremost arising salivary glands lesions could seem non-tender, generally gradually-progressing, mass formation in the oral or facial area. As there are several salivary glands beneath the mucosa that line the oral area, throat and sinus, hence lumpy appearance might be from this tumor form.
The signs could comprise of:
- Ingesting problems.
- Gruffness.
- Dulling pain.
- A lump or nodule formation close to the ears or beneath the jaws.
- Facial nerve getting paralysed.
- Loss of sensation of the facial area or the tongue.
- A lumpy appearance beneath the tongue or on the roof of the mouth.
